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Details on Person By ChIP in melanoma cells, MITF binds to an E-box at positio...
| Class:Id | Summation:9858603 |
|---|---|
| _displayName | By ChIP in melanoma cells, MITF binds to an E-box at positio... |
| _timestamp | 2024-04-04 16:23:11 |
| created | [InstanceEdit:9858610] Rothfels, Karen, 2024-01-13 |
| modified | [InstanceEdit:9859473] Rothfels, Karen, 2024-01-19 [InstanceEdit:9907117] Rothfels, Karen, 2024-04-04 |
| text | By ChIP in melanoma cells, MITF binds to an E-box at position -133 to -122 in the PLK1 (Polo-like kinase 1)promoter to drive expression. siRNA depletion of MITF in these cells reduces PLK1 protein levels. PLK1 was identified as one of a large number of genes involved in mitotic progression that are directly or indirectly regulated by MITF, contributing to the proliferative capacity of these cells (Strub et al, 2011; reviewed in Goding and Arnheiter, 2019). Inhibition of PLK1 in human melanomas reduces colonogenic survival, promotes multiple mitotic errors, G2/M cell-cycle arrest and apoptosis (Schmidt et al, 2009). |
| (summation) | [Reaction:9858639] MITF-M dimer binds the PLK1 gene [Homo sapiens] |
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No pathways have been reviewed or authored by By ChIP in melanoma cells, MITF binds to an E-box at positio... (9858603)
