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Details on Person MITF binds to an E-box element in the promoter of the CDKN1A...
| Class:Id | Summation:9858542 |
|---|---|
| _displayName | MITF binds to an E-box element in the promoter of the CDKN1A... |
| _timestamp | 2024-02-28 03:39:18 |
| created | [InstanceEdit:9858547] Rothfels, Karen, 2024-01-13 |
| modified | [InstanceEdit:9859473] Rothfels, Karen, 2024-01-19 [InstanceEdit:9863222] Rothfels, Karen, 2024-02-28 |
| text | MITF binds to an E-box element in the promoter of the CDKN1A gene as assessed by EMSA and ChIP in melanoma cells (Carreira et al, 2005). MITF binding stimulates CDKN1A expression in an E-box-dependent manner as demonstrated by reporter gene assay (Carreira et al, 2005). The CDKN1A gene encodes the G1 cyclin-dependent kinase inhibitor p21. CDKN1A activity is upregulated in cells with high levels of overall MITF activity and promotes exit from the cell cycle and activation of the MITF-dependent differentiation program (Carreira et al, 2005). The identification of the cell cycle inhibitor CDKN1A as an MITF target gene is somewhat at odds with the early characterization of MITF as a proliferative factor and its designation as a lineage survival oncogene (Widlund et al, 2002; Garraway et al, 2005). This paradox is explained by the rheostat model of MITF action (Carreira et al, 2006; reviewed in Goding and Arnheiter, 2019). In this model, cells with low overall levels of MITF activity exhibit a stem-cell-like phenotype, characterized by a low proliferation rate imposed by CDKN1B (p27kip1)-mediated cell cycle arrest, and high invasive potential by virtue of reorganization of the actin cytoskeleton and expression of matrix metalloproteases (Carreira et al, 2006). Cells with intermediate levels of MITF activity escape CDKN1B-imposed restraint on proliferation, while higher levels of MITF activity result in resumed cell-cycle arrest dependent on CDKN1A/p21 or the CDKN2A gene protein product p16 and a differentiation/pigmentation phenotype (Loercher et al, 2005; Carreira et al, 2005). |
| (summation) | [Reaction:9825835] MITF-M dimer binds the CDKN1A promoter [Homo sapiens] |
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No pathways have been reviewed or authored by MITF binds to an E-box element in the promoter of the CDKN1A... (9858542)
