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Details on Person MITF binds to the promoter of the BCL2 gene to upregulate it...
| Class:Id | Summation:9858296 |
|---|---|
| _displayName | MITF binds to the promoter of the BCL2 gene to upregulate it... |
| _timestamp | 2024-01-19 17:56:25 |
| created | [InstanceEdit:9858284] Rothfels, Karen, 2024-01-10 |
| modified | [InstanceEdit:9858400] Rothfels, Karen, 2024-01-12 [InstanceEdit:9859473] Rothfels, Karen, 2024-01-19 |
| text | MITF binds to the promoter of the BCL2 gene to upregulate its expression (McGill et al, 2002; Genovese et al, 2012). MITF-dependent regulation of the anti-apoptotic factor BCL2 contributes to the survival of the melanocyte lineage and to the progression of melanoma, as demonstrated by the loss of the melanocyte lineage in BCL2 knockout mice and in cell lines (Yamamura et al, 1996; Trisciuoglio et al, 2005; reviewed in Hou and Pavan, 2008; Cheli et al, 2010; Goding and Arnheiter, 2019; Soengas and Lowe, 2003). Overexpression of BCL2 decreases expression of the MITF target miR-211, decreases the proportion of nuclear MITF and reduces MITF occupancy on promoters of target genes such as GPR143 (also known as MLANA) and TRPM1 (De Luca et al, 2016). |
| (summation) | [BlackBoxEvent:9824587] MITF-M-dependent BCL2 expression [Homo sapiens] |
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No pathways have been reviewed or authored by MITF binds to the promoter of the BCL2 gene to upregulate it... (9858296)
