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Details on Person TRPM1 encodes a cation channel that allows passages of vario...

Class:IdSummation:9858285
_displayNameTRPM1 encodes a cation channel that allows passages of vario...
_timestamp2024-03-01 01:30:32
created[InstanceEdit:9858284] Rothfels, Karen, 2024-01-10
modified[InstanceEdit:9859473] Rothfels, Karen, 2024-01-19
[InstanceEdit:9863507] Rothfels, Karen, 2024-03-01
textTRPM1 encodes a cation channel that allows passages of various cations from the extracellular space into the cytoplasm (reviewed in Marini et al, 2023; Chubanov et al, 2023). TRPM1 has been identified as a direct target of MITF-M in melanocytes, retinal pigment epithelial cells and melanoma cells (Hunter et al, 1998; Miller et al, 2004; Miller et al, 2005; Strub et al, 2011). Expression is frequently downregulated during melanoma progression (Duncan et al, 1998; Duncan et al, 2001). The significance of TRPM1 downregulation in melanoma is unclear. Intron 6 of TRPM1 contains the MIR211 gene encoding microRNA miR-211 which is therefore similarly downregulated in melanoma. Targets of miR-211 include the MITF promoter binding protein POU3F2 (also known as BRN2), AP1S2, IGFBP5, SOX11 and SERINC3). How the changes in levels of TRPM1, miR-211 and miR-211 targets contribute to melanoma progression remains to be clarified (Margue et al, 2013; Levy et al, 2010; Boyle et al, 2011; De Luca et al, 2016; reviewed in Goding and Arnheiter, 2019).
(summation)[BlackBoxEvent:9858297] MITF-M-dependent TRPM1 expression [Homo sapiens]
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