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Details on Person Based on studies in African striped mouse, house mouse and c...
| Class:Id | Summation:9858219 |
|---|---|
| _displayName | Based on studies in African striped mouse, house mouse and c... |
| _timestamp | 2024-01-19 02:15:15 |
| created | [InstanceEdit:9858220] Rothfels, Karen, 2024-01-10 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 |
| text | Based on studies in African striped mouse, house mouse and chipmunk, ALX3 binds to conserved elements in the MITF promoter to repress transcription (Mallarino et al, 2016). ALX3 (aristaless-like homeobox 3) is a homeodomain protein that is expressed in neural crest derived mesenchyme and acts as a transcriptional regulator (ten Berge 1998; Perez-Villamil et al, 2004). Human and mouse ALX3 share ~90% identity and the three identified binding sites in the MITF promoter are conserved (Mallarino et al, 2016). Although in some cases ALX3 has been shown to bind DNA as a dimer, dimerization does not appear to be absolutely required and the DNA binding properties of ALX3 are impacted by interaction with other nuclear proteins and by the particular cellular environment (Perez-Villamil et al, 2004). The precise role of ALX3 in the regulation of melanocyte development and melanoma progression are not yet known. |
| (summation) | [Reaction:9858238] AXL3 binds MITF promoter [Homo sapiens] |
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No pathways have been reviewed or authored by Based on studies in African striped mouse, house mouse and c... (9858219)
