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Details on Person Based on a mouse model of hepatic steatosis, expression of t...
| Class:Id | Summation:9857989 |
|---|---|
| _displayName | Based on a mouse model of hepatic steatosis, expression of t... |
| _timestamp | 2024-04-11 15:38:37 |
| created | [InstanceEdit:9857988] Orlic-Milacic, Marija, 2024-01-09 |
| literatureReference | [LiteratureReference:9842041] Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARĪ³2 [LiteratureReference:9858073] H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development |
| modified | [InstanceEdit:9907275] Orlic-Milacic, Marija, 2024-04-05 [InstanceEdit:9907299] Orlic-Milacic, Marija, 2024-04-05 [InstanceEdit:9907518] Orlic-Milacic, Marija, 2024-04-11 |
| text | Based on a mouse model of hepatic steatosis, expression of the SCD5 (also known as SCD2 or SCD4) gene, encoding Stearoyl-CoA desaturase 5 that localizes to the endoplasmic reticulum membrane, is directly stimulated by PPARG2 and the KMT2D (MLL4) complex and negatively regulated by imatinib, an inhibitor of ABL1 kinase and consequently and inhibitor of ABL1-promoted association between PPARG2 and the MLL4 complex (Kim et al. 2016). Expression of the Scd4 gene, a mouse SCD5 ortholog, is severely reduced in differentiating mouse brown preadipocytes expressing histone H3.3 K4M mutant or Kmt2c (Mll3) and Kmt2d (Mll4) with deleted SET domains (Jang et al. 2019: RNA seq, supplementary information). |
| (summation) | [BlackBoxEvent:9854146] REVIEWERS CONSIDER EVIDENCE INSUFICIENT: SCD5 gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex [Homo sapiens] |
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No pathways have been reviewed or authored by Based on a mouse model of hepatic steatosis, expression of t... (9857989)
