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Details on Person prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)

Class:Id	Reaction:9857814
_displayName	prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface)
_doRelease	TRUE
_timestamp	2026-01-27 16:20:55
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
catalystActivity	[CatalystActivity:9855680] serine-type endopeptidase activity of KLKB1:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9857821] serine-type endopeptidase activity of FXII:C1QBP,C1QBP:KRT1, PLAUR:KRT1 [plasma membrane] Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9857816] Shamovsky, Veronica, 2024-01-09
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[Complex:9857822] KLKB1:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
literatureReference	[LiteratureReference:158373] Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate. [LiteratureReference:158378] Amino acid sequence of human beta-factor XIIa [LiteratureReference:158362] Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor [LiteratureReference:158349] Factor XII-dependent contact activation on endothelial cells and binding proteins gC1qR and cytokeratin 1 [LiteratureReference:158291] Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor) [LiteratureReference:158281] Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein. [LiteratureReference:158256] Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes [LiteratureReference:158249] The physiologic basis of assembly and activation of the plasma kallikrein/kinin system [LiteratureReference:9855707] Single-chain factor XII exhibits activity when complexed to polyphosphate
modified	[InstanceEdit:9909056] Shamovsky, Veronica, 2024-04-25 [InstanceEdit:9935716] Shamovsky, Veronica, 2025-01-18 [InstanceEdit:9936923] Shamovsky, Veronica, 2025-01-28 [InstanceEdit:9938639] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938677] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938820] Shamovsky, Veronica, 2025-02-19 [InstanceEdit:9938864] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9946125] Shamovsky, Veronica, 2025-04-21 [InstanceEdit:9979574] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980358] Shamovsky, Veronica, 2026-01-27
name	prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) KLKB1:KNG1:(C1QBP,C1QBP:KRT1, PLAUR:KRT1):FXII -> FXIIa + KLKB1:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1)
output	[Complex:158306] factor XIIa [extracellular region] [Homo sapiens] [Complex:9857960] KLKB1:KNG1:(C1QBP, C1QBP:KRT1, PLAUR:KRT1) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9855685] factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9857827] R-HSA-9857814.1
structureModified	[InstanceEdit:9909056] Shamovsky, Veronica, 2024-04-25
summation	[Summation:9936924] Binding of coagulation factor XII (FXII) to cell surface rec...
(hasEvent)	[Pathway:9855689] factor XIIa activates plasma kallikrein-kinin system [Homo sapiens] [Pathway:9970672] FXIIa activates plasma kallikrein-kinin system [Homo sapiens]
(precedingEvent)	[Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) [Homo sapiens]
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No pathways have been reviewed or authored by prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) (9857814)