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| Class:Id | Summation:9857745 |
|---|---|
| _displayName | Based on a mouse study, MLL4 binds to regulatory elements of... |
| _timestamp | 2024-01-09 15:06:06 |
| created | [InstanceEdit:9857744] Orlic-Milacic, Marija, 2024-01-08 |
| literatureReference | [LiteratureReference:9842041] Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARĪ³2 |
| modified | [InstanceEdit:9857761] Orlic-Milacic, Marija, 2024-01-08 [InstanceEdit:9857762] Orlic-Milacic, Marija, 2024-01-08 [InstanceEdit:9857983] Orlic-Milacic, Marija, 2024-01-09 [InstanceEdit:9857984] Orlic-Milacic, Marija, 2024-01-09 |
| text | Based on a mouse study, MLL4 binds to regulatory elements of the following genes induced during hepatic steatosis that are also bound by PPARG: ACSS3 (Kim et al. 2016); AGPAT2 (Kim et al. 2016); CD36 (Kim et al. 2016); CIDEC (Kim et al. 2016); ELOVL5 (Kim et al. 2016); GPAM (Kim et al. 2016); PLIN2 (Kim et al. 2016); SCD (also known as SCD1, Kim et al. 2016); SCD5 (also known as SCD2 or SCD4, Kim et al. 2016: Scd4 in mouse); THRSP (Kim et al. 2016). Mouse gene Scd3, also identified as a direct steatotic target of PPARG and MLL4, is not conserved in humans. Based on a study conducted in mouse liver carcinoma cell line, the association of PPARG1 and PPARG2 with MLL4 requires a PPARG agonist such as rosaglitazone (Kim et al. 2016). MLL4 binds to PPARG2 more robustly than to PPARG1 (Kim et al. 2016). The interaction between PPARG2 and MLL4 is diminished in the presence of the ABL1 inhibitor imatinib (Kim et al. 2016). ABL1-dependent phosphorylation of PPARG2 enhances association of PPARGw with MLL4 in mouse liver carcinoma cells. Imatinib, an inhibitor of ABL1 kinase, decreases association between PPARG2 and RBBP5, a component of the MLL4 complex and other KMT2 complexes (Kim et al. 2016). Imatinib significantly decreases the recruitment of MLL4 to PPREs (peroxisome proliferator response elements) in the PPARG, CD36, CIDEC and SCD gene loci (Kim et al. 2016). |
| (summation) | [BlackBoxEvent:9851871] MLL4-ASCOM,(MLL3-ASCOM) is recruited to PPARG2-bound regulatory elements of steatotic genes [Homo sapiens] |
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