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Details on Person Pannexin-1 (Panx1) channel transports ATP from the cytosol to the extracellular region

Class:Id	Reaction:9857696
_displayName	Pannexin-1 (Panx1) channel transports ATP from the cytosol to the extracellular region
_doRelease	TRUE
_timestamp	2024-11-05 13:28:24
authored	[InstanceEdit:9857469] May, Bruce, 2024-01-05
catalystActivity	[CatalystActivity:9857632] channel activity of Panx1 heptamer [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9857688] May, Bruce, 2024-01-08
edited	[InstanceEdit:9857469] May, Bruce, 2024-01-05
input	[SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9909074] Matthews, Lisa, 2024-04-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9857637] The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation [LiteratureReference:9863382] Purinergic P2Y2 receptor-induced activation of endothelial TRPV4 channels mediates lung ischemia-reperfusion injury
modified	[InstanceEdit:9863444] May, Bruce, 2024-02-29 [InstanceEdit:9906604] May, Bruce, 2024-03-31 [InstanceEdit:9915801] May, Bruce, 2024-07-16 [InstanceEdit:9925860] May, Bruce, 2024-10-27 [InstanceEdit:9927250] May, Bruce, 2024-11-05
name	Pannexin-1 (Panx1) channel transports ATP from the cytosol to the extracellular region
output	[SimpleEntity:114570] ATP [extracellular region]
regulatedBy	[PositiveRegulation:71542] Positive regulation by 'Ca2+ [cytosol]'
regulationReference	[RegulationReference:9906600] Positive regulation by 'Ca2+ [cytosol]' Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone
releaseDate	2024-09-11
reviewed	[InstanceEdit:9915793] Xiao, Rui, 2024-07-16 [InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9857718] R-MMU-9857696.2
structureModified	[InstanceEdit:9906604] May, Bruce, 2024-03-31
summation	[Summation:9863440] In the presence of potassium ions, Pannexin-1 (Panx1) forms ...
(inferredFrom)	[Reaction:9855161] Pannexin-1 (PANX1) channel transports ATP from the cytosol to the extracellular region [Homo sapiens] [Reaction:9905999] Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region [Homo sapiens]
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