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Details on Person p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region

Class:Id	Reaction:9857682
_displayName	p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region
_doRelease	TRUE
_timestamp	2024-11-05 13:30:27
authored	[InstanceEdit:9857469] May, Bruce, 2024-01-05
catalystActivity	[CatalystActivity:9857686] channel activity of p-S373-GJA1:p-S-ITGA5:ITGB1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9857688] May, Bruce, 2024-01-08
edited	[InstanceEdit:9857469] May, Bruce, 2024-01-05
inferredFrom	[Reaction:9857692] p-S373-Gja1:p-S-Itga5:Itgb1 transports prostagladin E2 (PGE2) from the cytosol to the extracellular region [Mus musculus]
input	[SimpleEntity:265287] PGE2 [cytosol]
internalReviewed	[InstanceEdit:9909074] Matthews, Lisa, 2024-04-26
isChimeric	FALSE
modified	[InstanceEdit:9907495] May, Bruce, 2024-04-10 [InstanceEdit:9925860] May, Bruce, 2024-10-27 [InstanceEdit:9927250] May, Bruce, 2024-11-05
name	p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region
output	[SimpleEntity:391930] PGE2 [extracellular region]
precedingEvent	[Reaction:9857703] p-S-ITGA5:ITGB1 binds p-S373-GJA1 [Homo sapiens] [Reaction:9857661] p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43) [Homo sapiens] [Reaction:9857673] p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1) [Homo sapiens]
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9857724] R-HSA-9857682.1
summation	[Summation:9907478] Mechanical strain on osteocytes causes the osteocytes to rel...
(hasEvent)	[Pathway:9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes [Homo sapiens]
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No pathways have been reviewed or authored by p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region (9857682)