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Details on Person p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)

Class:Id	Reaction:9857673
_displayName	p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)
_doRelease	TRUE
_timestamp	2024-11-05 13:31:36
authored	[InstanceEdit:9857469] May, Bruce, 2024-01-05
catalystActivity	[CatalystActivity:450501] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9857688] May, Bruce, 2024-01-08
edited	[InstanceEdit:9857469] May, Bruce, 2024-01-05
inferredFrom	[Reaction:9857664] p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1) [Mus musculus]
input	[Complex:9857675] ITGA5:ITGB1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9909074] Matthews, Lisa, 2024-04-26
isChimeric	FALSE
modified	[InstanceEdit:9906805] May, Bruce, 2024-04-02 [InstanceEdit:9907621] May, Bruce, 2024-04-14 [InstanceEdit:9925860] May, Bruce, 2024-10-27 [InstanceEdit:9927250] May, Bruce, 2024-11-05
name	p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1)
output	[Complex:9857677] p-S-ITGA5:ITGB1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:9906597] Activation of AKT1 by shear stress in osteocytes [Homo sapiens] [Reaction:9855089] PIEZO1 trimer passively transports cations across the plasma membrane according to their electrochemical gradients [Homo sapiens] [Reaction:9905934] CaV3.2 (CACNA1H:CACNA2D1:CACNB1,2,3:CACNG7) transports calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:9905964] P2RX7 in ATP:P2RX7:PANX1 transports cations from the extracellular region to the cytosol [Homo sapiens]
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9857726] R-HSA-9857673.1
summation	[Summation:9907612] AKT1 phosphorylated on threonine-308 and serine-475 phosphor...
(hasEvent)	[Pathway:9856532] Mechanical load activates signaling by PIEZO1 and integrins in osteocytes [Homo sapiens]
(precedingEvent)	[Reaction:9857703] p-S-ITGA5:ITGB1 binds p-S373-GJA1 [Homo sapiens]
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No pathways have been reviewed or authored by p-T308,S473-AKT1 phosphorylates ITGA5 (Integrin alpha5) in ITGA5:ITGB1 (Integrin alpha5:Integrin beta1) (9857673)