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Details on Person Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation
| Class:Id | LiteratureReference:9857659 |
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| _displayName | Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation |
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| _timestamp | 2024-01-08 16:11:27 |
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| author | [Person:9857674] Batra, Nidhi
[Person:9857687] Riquelme, Manuel A
[Person:9857700] Burra, Sirisha
[Person:9857695] Kar, Rekha
[Person:9857681] Gu, Sumin
[Person:9857630] Jiang, Jean X |
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| created | [InstanceEdit:9857688] May, Bruce, 2024-01-08 |
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| journal | J Biol Chem |
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| pages | 10582-10591 |
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| pubMedIdentifier | 24563481 |
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| title | Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation |
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| volume | 289 |
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| year | 2014 |
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| (literatureReference) | [Summation:9906592] In response to mechanical loading, the integrin alphaVbeta3 ...
[Summation:9907478] Mechanical strain on osteocytes causes the osteocytes to rel...
[RegulationReference:9909063] Positive regulation by 'Itgav:Itgb3 [plasma membrane]' Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation
[Reaction:9857656] Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1) [Mus musculus]
[Reaction:9857664] p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1) [Mus musculus]
[Reaction:9857679] p-S-Itga5:Itgb1 binds p-S373-Gja1 [Mus musculus]
[Reaction:9857692] p-S373-Gja1:p-S-Itga5:Itgb1 transports prostagladin E2 (PGE2) from the cytosol to the extracellular region [Mus musculus]
[BlackBoxEvent:9906595] Activation of Akt1 by shear stress in osteocytes [Mus musculus]
[Complex:9857634] p-S373-Gja1 hemichannel [plasma membrane] [Mus musculus]
[Complex:9857694] p-S373-Gja1:p-S-Itga5:Itgb1 [plasma membrane] [Mus musculus] |
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