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Details on Person Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)

Class:Id	Reaction:9857656
_displayName	Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)
_doRelease	TRUE
_timestamp	2024-11-05 13:29:02
authored	[InstanceEdit:9857469] May, Bruce, 2024-01-05
catalystActivity	[CatalystActivity:162361] protein serine/threonine kinase activity of p-T308,S473-Akt1 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9857688] May, Bruce, 2024-01-08
edited	[InstanceEdit:9857469] May, Bruce, 2024-01-05
input	[Complex:9857641] Connexin-43 hemichannel [plasma membrane] [Mus musculus] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9909074] Matthews, Lisa, 2024-04-26
isChimeric	FALSE
literatureReference	[LiteratureReference:9857659] Direct regulation of osteocytic connexin 43 hemichannels through AKT kinase activated by mechanical stimulation
modified	[InstanceEdit:9907611] May, Bruce, 2024-04-13 [InstanceEdit:9925860] May, Bruce, 2024-10-27 [InstanceEdit:9927250] May, Bruce, 2024-11-05
name	Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)
output	[Complex:9857634] p-S373-Gja1 hemichannel [plasma membrane] [Mus musculus] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2024-12-04
reviewed	[InstanceEdit:9925857] Farach-Carson, Mary C, 2024-10-27 [InstanceEdit:9925859] Wu, Danielle, 2024-10-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9857725] R-MMU-9857656.1
summation	[Summation:9907606] Akt1 phosphorylated in response to mechanical loading direct...
(inferredFrom)	[Reaction:9857661] p-T308,S473-AKT1 (phospho-PKB) phosphorylates GJA1 (Connexin-43) [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1) (9857656)