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Details on Person DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Class:Id	CatalystActivityReference:9857478
_displayName	DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
_timestamp	2024-02-11 19:51:12
catalystActivity	[CatalystActivity:9856544] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm]
created	[InstanceEdit:9857474] D'Eustachio, Peter, 2024-01-05
literatureReference	[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. [LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver [LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription [LiteratureReference:164120] Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes
modified	[InstanceEdit:9857485] D'Eustachio, Peter, 2024-01-05 [InstanceEdit:9860885] D'Eustachio, Peter, 2024-02-11
(catalystActivityReference)	[Reaction:9856539] MLXIPL:MLX binds PKLR gene promoter [Homo sapiens] [Reaction:9856546] MLXIPL:MLX binds FASN gene promoter [Homo sapiens] [Reaction:9856548] MLXIPL:MLX binds ACACB gene promoter [Homo sapiens] [Reaction:9856549] MLXIPL:MLX binds ACLY gene promoter [Homo sapiens] [Reaction:9856550] MLXIPL:MLX binds ACACA gene promoter [Homo sapiens] [Reaction:9856604] MLXIPL:MLX binds AGPAT1 gene promoter [Homo sapiens]
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No pathways have been reviewed or authored by DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. (9857478)