Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Changes in relative levels of E- and N-cadherin contribute t...
| Class:Id | Summation:9857457 |
|---|---|
| _displayName | Changes in relative levels of E- and N-cadherin contribute t... |
| _timestamp | 2024-04-04 16:23:11 |
| created | [InstanceEdit:9857456] Rothfels, Karen, 2024-01-04 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 [InstanceEdit:9907117] Rothfels, Karen, 2024-04-04 |
| text | Changes in relative levels of E- and N-cadherin contribute to migration of neural crest cells during melanocyte differentiation, and also play a role during the development of melanoma (Li et al, 2001; Gupta et al, 2005; LaBonne et al, 2000; reviewed in Mort et al, 2015). CDH1, the gene encoding E-cadherin, is downregulated during melanocyte development to allow epithelial-to-mesenchymal transition and associated cell migration to occur (Cano et al, 2000; reviewed in White and Zon, 2008). Signaling through endothelin receptor B (ENDRB) also contributes to the migration of melanocyte precursors by downregulating expression of CDH1 and upregulating expression of CDH2 encoding N-cadherin (Bagnato et al, 2004). CDH1 expression is repressed by binding of SNAI2, also known as SLUG or SNAIL2, to E-boxes in the promoter, as demonstrated in by EMSA and ChIP in MDCK and in synovial sarcoma cell lines (Hayashida et al, 2006; Saito et al, 2006), In human breast cancer cell lines, overexpression of SNAI2 represses transcription of endogenous CDH1 gene (Hajra et al. 2002). TBX3 is a member of the T-box transcription factor family of proteins that are involved in establishing and maintaining cell identity (Niu et al, 2021). TBX3 binds to the promoter of the CDH1 gene to repress its expression as demonstrated by EMSA, ChIP and reporter gene assay (Rodriguez et al, 2008). |
| (summation) | [BlackBoxEvent:9825774] SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Changes in relative levels of E- and N-cadherin contribute t... (9857457)
