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Details on Person TBX2 (T-box transcription factor 2) is a member of the T-box...
| Class:Id | Summation:9857347 |
|---|---|
| _displayName | TBX2 (T-box transcription factor 2) is a member of the T-box... |
| _timestamp | 2024-11-06 20:30:33 |
| created | [InstanceEdit:9857351] Rothfels, Karen, 2024-01-04 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 [InstanceEdit:9927491] Rothfels, Karen, 2024-11-06 |
| text | TBX2 (T-box transcription factor 2) is a member of the T-box family of transcription factors that play a role in establishing cell identity during embryonic development and contribute to the development of cancer (reviewed in Abrahams et al, 2010; Niu et al, 2021). TBX2 is expressed in melanoblasts and melanocytes but is not expressed in melanoblast precursors of the neural crest, and its expression may therefore be linked to establishment and maintenance of melanocyte lineage identity (Carreira et al, 1998). TBX2 is also expressed in a number of MITF-expressing melanoma cell lines but not in the MITF-negative K1735 cell line (Carreira et al, 2000). Analysis of the TBX2 promoter in mouse has identified an E-box element between positions-332 and -327 that drives MITF-dependent reporter gene expression and is bound by MITF in electrophoretic mobility shift assay (EMSA) (Carreira et al, 2000). Consistent with this, TBX2 was identified as a direct MITF target in human melanoma lines by ChIP-seq (Strub et al, 2011). TBX2 is a negative regulator of TYRP1 gene expression. TYRP1 contributes both to the enzymatic steps of melanin synthesis and has also been implicated in the regulation of melanocyte proliferation (Carreira et al, 1998; Sarangarajan et al, 2000; reviewed in Cheli et al, 2010). TBX2 may additionally impact MITF-dependent proliferation and cell cycle by virtue of its activation of Cyclin D expression as demonstrated in mouse melanocytes, as well as by repressing expression of the cell cycle inhibitors CDKN1A (p21) and the CDKN2A gene-protein product p14ARF (p19 ARF in mouse) (Pan et al, 2015; Jacobs et al, 2000; Prince et al, 2004; Vance et al, 2005; reviewed in Cheli et al, 2010). |
| (summation) | [Reaction:9825845] MITF-M dimer binds the TBX2 gene [Homo sapiens] |
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No pathways have been reviewed or authored by TBX2 (T-box transcription factor 2) is a member of the T-box... (9857347)
