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Details on Person MITF regulates biogenesis of organelles such as the lysosome...
| Class:Id | Summation:9857345 |
|---|---|
| _displayName | MITF regulates biogenesis of organelles such as the lysosome... |
| _timestamp | 2024-03-01 01:30:19 |
| created | [InstanceEdit:9857351] Rothfels, Karen, 2024-01-04 |
| modified | [InstanceEdit:9863506] Rothfels, Karen, 2024-03-01 |
| text | MITF regulates biogenesis of organelles such as the lysosome and endosomes through its regulation of components of the V-ATPase that is required for organelle acidification and function (Zhang et al, 2015; Ploper et al, 2015a; reviewed in Ploper et al, 2015b). MITF-dependent targets also contribute to autophagy when cells are stressed for nutrients (Möller et al, 2019). MITF additionally controls expression of the lysosome-resident acid ceramidase ASAH1 that has roles in sphingolipid metabolism and cellular proliferation in melanoma (Leclerc et al, 2019; Realini et al, 2016). |
| (summation) | [Pathway:9857377] Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy [Homo sapiens] |
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No pathways have been reviewed or authored by MITF regulates biogenesis of organelles such as the lysosome... (9857345)
