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Details on Person HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization

Class:Id	BlackBoxEvent:9857091
_displayName	HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization
_doRelease	TRUE
_timestamp	2024-11-08 06:39:32
authored	[InstanceEdit:9857055] May, Bruce, 2023-12-30
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9857073] May, Bruce, 2023-12-31
edited	[InstanceEdit:9857055] May, Bruce, 2023-12-30
input	[EntityWithAccessionedSequence:3371452] HSF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3371452] HSF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3371452] HSF1 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9858315] Matthews, Lisa, 2024-01-11 [InstanceEdit:9919312] Matthews, Lisa, 2024-08-21 [InstanceEdit:9927586] Matthews, Lisa, 2024-03-08
isChimeric	FALSE
literatureReference	[LiteratureReference:9857048] A cytosolic surveillance mechanism activates the mitochondrial UPR [LiteratureReference:9857040] HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response [LiteratureReference:4793691] Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1
modified	[InstanceEdit:9859421] May, Bruce, 2024-01-19 [InstanceEdit:9918121] May, Bruce, 2024-08-14 [InstanceEdit:9919313] Matthews, Lisa, 2024-08-21 [InstanceEdit:9927588] Matthews, Lisa, 2024-11-08
name	HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization
output	[Complex:5082354] p-S326-HSF1 trimer [nucleoplasm] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9857076] Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 [Homo sapiens] [Reaction:9857090] Reactive oxygen species oxidize DNAJA1 [Homo sapiens]
releaseDate	2024-09-11
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9857106] R-HSA-9857091.2
structureModified	[InstanceEdit:9859421] May, Bruce, 2024-01-19
summation	[Summation:9857086] During the mitochondrial unfolded protein response (mtUPR), ...
(hasEvent)	[Pathway:9841251] Mitochondrial unfolded protein response (UPRmt) [Homo sapiens]
(precedingEvent)	[Reaction:9857071] ATF5 and HSF1 trimer bind the bidirectional promoter of the HSPD1 gene and HSPE1 gene [Homo sapiens] [Reaction:9857083] ATF5 and HSF1 trimer bind the HSPA9 gene [Homo sapiens]
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