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Details on Person Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1

Class:IdReaction:9857076
_displayNameOxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1
_doReleaseTRUE
_timestamp2024-08-14 12:51:40
authored[InstanceEdit:9857055] May, Bruce, 2023-12-30
compartment[Compartment:70101] cytosol
created[InstanceEdit:9857073] May, Bruce, 2023-12-31
edited[InstanceEdit:9857055] May, Bruce, 2023-12-30
input[Complex:9857081] HSF1:HSPA1A,B [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9857072] SOH-C149,C150-DNAJA1 [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9858315] Matthews, Lisa, 2024-01-11
isChimericFALSE
literatureReference[LiteratureReference:9857048] A cytosolic surveillance mechanism activates the mitochondrial UPR
modified[InstanceEdit:9918121] May, Bruce, 2024-08-14
nameOxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1
output[Complex:9857087] HSPA1A,B:ox-C149,C150-DNAJA1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:3371452] HSF1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2024-09-11
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9857102] R-HSA-9857076.1
summation[Summation:9857075] Oxidized DNAJA1 and, possibly, mitochondrial proteins strand...
(hasEvent)[Pathway:9841251] Mitochondrial unfolded protein response (UPRmt) [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization [Homo sapiens]
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