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Details on Person MDH1 reduces OA

Class:Id	Reaction:9856871
_displayName	MDH1 reduces OA
_doRelease	TRUE
_timestamp	2025-05-28 08:09:32
authored	[InstanceEdit:9856870] Stephan, Ralf, 2023-12-26
catalystActivity	[CatalystActivity:198512] L-malate dehydrogenase (NAD+) activity of MDH1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9815320] L-malate dehydrogenase activity of MDH1 dimer [cytosol] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9856869] Stephan, Ralf, 2023-12-26
crossReference	[DatabaseIdentifier:9856873] RHEA:21434
edited	[InstanceEdit:9859599] Stephan, Ralf, 2024-01-22
input	[SimpleEntity:73473] NADH [cytosol] [SimpleEntity:76213] OA [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9857487] D'Eustachio, Peter, 2024-01-07
literatureReference	[LiteratureReference:198443] Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution [LiteratureReference:9815321] Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes [LiteratureReference:198469] Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1) [LiteratureReference:9854286] Cytosolic malate dehydrogenase regulates senescence in human fibroblasts [LiteratureReference:9857025] MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy [LiteratureReference:9857026] Structural Characterization of the Human Cytosolic Malate Dehydrogenase I [LiteratureReference:9857057] The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway
modified	[InstanceEdit:9856910] Stephan, Ralf, 2023-12-28 [InstanceEdit:9857024] Stephan, Ralf, 2023-12-30 [InstanceEdit:9857061] Stephan, Ralf, 2023-12-31 [InstanceEdit:9857486] Stephan, Ralf, 2024-01-07 [InstanceEdit:9859509] Stephan, Ralf, 2024-01-20 [InstanceEdit:9859599] Stephan, Ralf, 2024-01-22 [InstanceEdit:9861219] D'Eustachio, Peter, 2024-02-15 [InstanceEdit:9863536] Stephan, Ralf, 2024-03-01 [InstanceEdit:9953017] Stephan, Ralf, 2025-05-28 [InstanceEdit:9964569] Matthews, Lisa, 2025-08-25
name	MDH1 reduces OA
output	[SimpleEntity:198498] MAL [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
precedingEvent	[Reaction:70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Homo sapiens] [Reaction:372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] [Homo sapiens] [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens] [Reaction:372448] SLC25A12,13 exchange L-Glu and L-Asp [Homo sapiens] [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate [Homo sapiens] [Reaction:6797627] ASPG hydrolyses L-Asn to L-Asp [Homo sapiens] [Reaction:70449] GADPH tetramer dehydrogenates GA3P [Homo sapiens] [Reaction:70454] TPI1 dimer isomerizes DHAP to GA3P [Homo sapiens] [Reaction:70349] DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate [Homo sapiens] [Reaction:977348] PHGDH tetramer dehydrogenates 3PG [Homo sapiens] [Reaction:390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA [Homo sapiens] [Reaction:390252] HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA [Homo sapiens] [Reaction:6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA [Homo sapiens] [Reaction:6809264] EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA [Homo sapiens] [Reaction:6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9861220] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9856875] R-HSA-9856871.3
summation	[Summation:198450] Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the revers...
(hasEvent)	[Pathway:9856872] Malate-aspartate shuttle [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9953021] Futile Cycle: MDH1 reduces OA [Reaction:376851] SLC25A11 exchanges 2-OG and MAL [Homo sapiens]
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No pathways have been reviewed or authored by MDH1 reduces OA (9856871)