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Details on Person Mitochondrial 4-hydroxyphenylpyruvate dioxygenase-like prote...
| Class:Id | Summation:9856721 |
|---|---|
| _displayName | Mitochondrial 4-hydroxyphenylpyruvate dioxygenase-like prote... |
| _timestamp | 2023-12-22 09:30:04 |
| created | [InstanceEdit:9856699] Stephan, Ralf, 2023-12-22 |
| text | Mitochondrial 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) was shown to process 4-hydroxphenylpyruvate (HPPA) to (S)-4-hydroxymandelate (4-HMA). HPDL defects lead to CoQ10 deficiency, and the HPDL product 4-hydroxymandelate apparently is a precursor for the synthesis of 4-hydroxybenzoate, which is a prerequisite for the assembly of the CoQ10 head group (Banh et al., 2021). Because HPDL is a mitochondrial protein, cytosolic HPPA from tyrosine catabolism must be imported by an unknown transport mechanism (Husain et al., 2020; reviewed in Staiano et al., 2023). |
| (summation) | [Reaction:9856718] HPDL dioxygenates HPPA [Homo sapiens] |
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No pathways have been reviewed or authored by Mitochondrial 4-hydroxyphenylpyruvate dioxygenase-like prote... (9856721)
