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Details on Person ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)

Class:Id	BlackBoxEvent:9856627
_displayName	ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)
_doRelease	TRUE
_timestamp	2024-08-14 12:47:52
authored	[InstanceEdit:9856621] May, Bruce, 2023-12-19
compartment	[Compartment:7660] nucleoplasm [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9856626] May, Bruce, 2023-12-20
edited	[InstanceEdit:9856621] May, Bruce, 2023-12-19
input	[EntityWithAccessionedSequence:8950249] HSPA9 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9858315] Matthews, Lisa, 2024-01-11
isChimeric	FALSE
literatureReference	[LiteratureReference:9841851] The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR [LiteratureReference:9857048] A cytosolic surveillance mechanism activates the mitochondrial UPR
modified	[InstanceEdit:9856678] May, Bruce, 2023-12-21 [InstanceEdit:9856847] May, Bruce, 2023-12-23 [InstanceEdit:9857055] May, Bruce, 2023-12-30 [InstanceEdit:9857110] May, Bruce, 2023-12-31 [InstanceEdit:9918121] May, Bruce, 2024-08-14
name	ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)
output	[EntityWithAccessionedSequence:8878802] HSPA9 [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:9857083] ATF5 and HSF1 trimer bind the HSPA9 gene [Homo sapiens] [BlackBoxEvent:9841247] ATF5 translocates from the cytosol to the nucleoplasm [Homo sapiens] [BlackBoxEvent:9857091] HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9857093] Positive gene expression regulation by 'ATF5:HSF1 trimer:HSPA9 gene [nucleoplasm]'
regulationReference	[RegulationReference:9857092] Positive gene expression regulation by 'ATF5:HSF1 trimer:HSPA9 gene [nucleoplasm]' A cytosolic surveillance mechanism activates the mitochondrial UPR
releaseDate	2024-09-11
requiredInputComponent	[Complex:5082354] p-S326-HSF1 trimer [nucleoplasm] [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9856635] R-HSA-9856627.1
structureModified	[InstanceEdit:9856678] May, Bruce, 2023-12-21 [InstanceEdit:9856847] May, Bruce, 2023-12-23 [InstanceEdit:9857110] May, Bruce, 2023-12-31
summation	[Summation:9857049] During the mitochondrial response to unfolded protein (mtUPR...
(hasEvent)	[Pathway:9841251] Mitochondrial unfolded protein response (UPRmt) [Homo sapiens]
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No pathways have been reviewed or authored by ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70) (9856627)