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Details on Person MLXIPL:MLX binds ACACA gene promoter

Class:Id	Reaction:9856550
_displayName	MLXIPL:MLX binds ACACA gene promoter
_doRelease	TRUE
_timestamp	2024-03-01 13:07:54
authored	[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
catalystActivity	[CatalystActivity:9856544] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9857478] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
edited	[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
input	[Complex:163700] MLXIPL:MLX [nucleoplasm] [Homo sapiens] [Complex:163700] MLXIPL:MLX [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9856497] ACACA gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. [LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver [LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
modified	[InstanceEdit:9856561] D'Eustachio, Peter, 2023-12-19 [InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20 [InstanceEdit:9856745] D'Eustachio, Peter, 2023-12-22 [InstanceEdit:9857279] D'Eustachio, Peter, 2024-01-03 [InstanceEdit:9857474] D'Eustachio, Peter, 2024-01-05 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12 [InstanceEdit:9863550] D'Eustachio, Peter, 2024-03-01
name	MLXIPL:MLX binds ACACA gene promoter
output	[Complex:9856540] MLXIPL:MLX:ACACA gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:163666] Formation of ChREBP:MLX heterodimer [Homo sapiens] [Reaction:164056] Dephosphorylation of pChREBP (Ser 556) by PP2A [Homo sapiens] [Reaction:163688] Dephosphorylation of pChREBP (Thr 666) by PP2A [Homo sapiens]
releaseDate	2024-03-27
reviewed	[InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9856560] R-HSA-9856550.1
structureModified	[InstanceEdit:9857279] D'Eustachio, Peter, 2024-01-03
summation	[Summation:9857471] As part of the physiological response to high dietary carboh...
(hasEvent)	[Pathway:163765] ChREBP activates metabolic gene expression [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:163743] Transcriptional activation of ACACA by ChREBP:MLX [Homo sapiens]
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No pathways have been reviewed or authored by MLXIPL:MLX binds ACACA gene promoter (9856550)