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Details on Person MLXIPL:MLX binds PKLR gene promoter

Class:IdReaction:9856539
_displayNameMLXIPL:MLX binds PKLR gene promoter
_doReleaseTRUE
_timestamp2024-03-01 13:08:01
authored[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
catalystActivity[CatalystActivity:9856544] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9857478] DNA-binding transcription activator activity, RNA polymerase II-specific of MLXIPL:MLX [nucleoplasm] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
edited[InstanceEdit:9856547] D'Eustachio, Peter, 2023-12-19
input[Complex:163700] MLXIPL:MLX [nucleoplasm] [Homo sapiens]
[Complex:163700] MLXIPL:MLX [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9606134] PKLR gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:164080] Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
[LiteratureReference:8984798] ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver
[LiteratureReference:8984350] A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription
[LiteratureReference:164120] Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes
modified[InstanceEdit:9856561] D'Eustachio, Peter, 2023-12-19
[InstanceEdit:9856606] D'Eustachio, Peter, 2023-12-20
[InstanceEdit:9856745] D'Eustachio, Peter, 2023-12-22
[InstanceEdit:9857279] D'Eustachio, Peter, 2024-01-03
[InstanceEdit:9857474] D'Eustachio, Peter, 2024-01-05
[InstanceEdit:9860885] D'Eustachio, Peter, 2024-02-11
[InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
[InstanceEdit:9863550] D'Eustachio, Peter, 2024-03-01
nameMLXIPL:MLX binds PKLR gene promoter
output[Complex:9856541] MLXIPL:MLX:PKLR gene [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2024-03-27
reviewed[InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9856557] R-HSA-9856539.1
structureModified[InstanceEdit:9857279] D'Eustachio, Peter, 2024-01-03
summation[Summation:9857481] As part of the physiological response to high dietary carboh...
(hasEvent)[Pathway:163765] ChREBP activates metabolic gene expression [Homo sapiens]
(precedingEvent)[BlackBoxEvent:163669] Transcriptional activation of PKLR gene by ChREBP:MLX [Homo sapiens]
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No pathways have been reviewed or authored by MLXIPL:MLX binds PKLR gene promoter (9856539)
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