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Details on Person MLPH/MYRIP bind GGC-RAB27A and MYO5A

Class:Id	Reaction:9856465
_displayName	MLPH/MYRIP bind GGC-RAB27A and MYO5A
_doRelease	TRUE
_timestamp	2024-11-08 15:58:18
authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:9856459] Rothfels, Karen, 2023-12-18
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
input	[Complex:9605106] p-S1652-MYO5A dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8877281] GGC-RAB27A [melanosome membrane] [Homo sapiens] [DefinedSet:9856440] MLPH,MYRIP [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9856433] SYTL2 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9732023] Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport [LiteratureReference:9732019] MYO5A Gene Is a Target of MITF in Melanocytes [LiteratureReference:9856416] Rab GTPases and myosin motors in organelle motility [LiteratureReference:9856397] Melanosomes on the move: a model to understand organelle dynamics [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9856394] Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions [LiteratureReference:9856398] MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes [LiteratureReference:9856429] Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport [LiteratureReference:9856425] Rab27a: A key to melanosome transport in human melanocytes [LiteratureReference:9856410] Myosin-Va contributes to manifestation of malignant-related properties in melanoma cells [LiteratureReference:9856404] Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport [LiteratureReference:9856421] Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes [LiteratureReference:9856375] A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion [LiteratureReference:9856389] Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain
modified	[InstanceEdit:9863246] Rothfels, Karen, 2024-02-28 [InstanceEdit:9907153] Rothfels, Karen, 2024-04-04 [InstanceEdit:9909022] Rothfels, Karen, 2024-04-25 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
name	MLPH/MYRIP bind GGC-RAB27A and MYO5A
output	[Complex:9856444] GGC-RAB27A:MLPH,MYRIP:SYTL2:p-S1652-MYO5A dimer [melanosome membrane] [Homo sapiens]
precedingEvent	[Reaction:1449597] p-AKT2 phosphorylates Myosin 5A [Homo sapiens] [Reaction:109702] PDPK1 phosphorylates AKT2 [Homo sapiens] [BlackBoxEvent:9856462] MITF-M-dependent MYO5A expression [Homo sapiens] [BlackBoxEvent:9856460] MITF-M-dependent RAB27A expression [Homo sapiens] [Reaction:9856466] MITF-M dimer binds RAB27A gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewed	[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9856471] R-HSA-9856465.2
summation	[Summation:9856453] MITF-M-dependent transcriptional targets RAB27A and MYO5A pl...
(hasEvent)	[Pathway:9824585] Regulation of MITF-M-dependent genes involved in pigmentation [Homo sapiens]
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No pathways have been reviewed or authored by MLPH/MYRIP bind GGC-RAB27A and MYO5A (9856465)