Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person MITF-M-dependent transcriptional targets RAB27A and MYO5A pl...

Class:IdSummation:9856453
_displayNameMITF-M-dependent transcriptional targets RAB27A and MYO5A pl...
_timestamp2024-01-19 02:15:33
created[InstanceEdit:9856454] Rothfels, Karen, 2023-12-18
modified[InstanceEdit:9859417] Rothfels, Karen, 2024-01-19
textMITF-M-dependent transcriptional targets RAB27A and MYO5A play a role in melanosome organization and maturation by regulating melanosome distribution (Chiaverini et al, 2008; Alves et al, 2017; reviewed in Hume and Seabra, 2011; Seabra and Coudrier, 2004; Cheli et al, 2010; Goding and Arnheiter, 2019). Melanosome-bound RAB27A and the actin-binding protein MYO5A form a complex mediated by the RAB effector protein MLPH, also known as melanophilin, or the RAB effector MYRIP (Nagashima et al, 2002; El-Amraoui et al, 2002). This heteromeric complex directs localization of melanosomes to the tips of dendrites prior to loading of melanosomes into adjacent keratinocytes (Bahadoran et al, 2001; Nagashima et al, 2002; El-Amraoui et al, 2002; Fukuda et al, 2002; Alves et al, 2013; Evans et al, 2014; Alves et al, 2017). Docking at the plasma membrane may be facilitated by SYTL2, another RAB27A-binding protein (Kuroda and Fukuda, 2004; Menasche et al, 2008; Yu et al, 2007. Note that the existence of a complex containing each of SYTL2, RAB27A, MYO5A and either MLPH or MYRIP has not been explicitly demonstrated.
(summation)[Reaction:9856465] MLPH/MYRIP bind GGC-RAB27A and MYO5A [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by MITF-M-dependent transcriptional targets RAB27A and MYO5A pl... (9856453)
Follow Reactome