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Details on Person Mll4,(Mll3)-ASCOM monomethylates nucleosomes at Pparg:Rxra-bound enhancers

Class:Id	Reaction:9856368
_displayName	Mll4,(Mll3)-ASCOM monomethylates nucleosomes at Pparg:Rxra-bound enhancers
_doRelease	TRUE
_timestamp	2025-11-04 01:48:33
authored	[InstanceEdit:9856363] Orlic-Milacic, Marija, 2023-12-18
catalystActivity	[CatalystActivity:9919233] histone methyltransferase activity (H3-K4 specific) of Activated Pparg:Rxra:adipogenesis genes:nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9856363] Orlic-Milacic, Marija, 2023-12-18
edited	[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
input	[DefinedSet:9919132] Activated Pparg:Rxra:adipogenesis genes:nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] [Mus musculus] [SimpleEntity:77087] AdoMet [nucleoplasm]
internalReviewed	[InstanceEdit:9907495] May, Bruce, 2024-04-10 [InstanceEdit:9919249] May, Bruce, 2024-08-19 [InstanceEdit:9927587] May, Bruce, 2024-03-08 [InstanceEdit:9928383] Matthews, Lisa, 2024-11-15
isChimeric	FALSE
literatureReference	[LiteratureReference:9858073] H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development [LiteratureReference:9856351] Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis [LiteratureReference:9842041] Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2 [LiteratureReference:9851793] Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis
modified	[InstanceEdit:9858077] Orlic-Milacic, Marija, 2024-01-10 [InstanceEdit:9906980] Orlic-Milacic, Marija, 2024-04-04 [InstanceEdit:9907517] Orlic-Milacic, Marija, 2024-04-11 [InstanceEdit:9907544] Orlic-Milacic, Marija, 2024-04-12 [InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9919218] Orlic-Milacic, Marija, 2024-08-19 [InstanceEdit:9919248] Orlic-Milacic, Marija, 2024-08-19 [InstanceEdit:9919251] Orlic-Milacic, Marija, 2024-08-19 [InstanceEdit:9927588] Matthews, Lisa, 2024-11-08 [InstanceEdit:9928382] Matthews, Lisa, 2024-11-15 [InstanceEdit:9971003] Orlic-Milacic, Marija, 2025-11-04
name	Mll4,(Mll3)-ASCOM monomethylates nucleosomes at Pparg:Rxra-bound enhancers
output	[DefinedSet:9919231] Activated Pparg:Rxra:adipogenesis genes:H3K4me1-nucleosomes:Mll4,(Mll3)-ASCOM [nucleoplasm] [Mus musculus] [SimpleEntity:77502] AdoHcy [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-09-11
reviewed	[InstanceEdit:9970977] Khag, Joy, 2025-10-31 [InstanceEdit:9970978] Wang, Shu-Ping, 2025-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9856373] R-MMU-9856368.3
structureModified	[InstanceEdit:9919248] Orlic-Milacic, Marija, 2024-08-19
summation	[Summation:9856366] In mouse embryonic fibroblasts (MEFs), which only express Pp...
(inferredFrom)	[Reaction:9843121] MLL4-ASCOM, (MLL3-ASCOM) complex monomethylates nucleosomes at PPARG:RXRA-bound enhancers [Homo sapiens]
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No pathways have been reviewed or authored by Mll4,(Mll3)-ASCOM monomethylates nucleosomes at Pparg:Rxra-bound enhancers (9856368)