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Details on Person In differentiating mouse brown adipocytes, KMT2D (MLL4) main...
| Class:Id | Summation:9856367 |
|---|---|
| _displayName | In differentiating mouse brown adipocytes, KMT2D (MLL4) main... |
| _timestamp | 2024-04-11 15:39:15 |
| created | [InstanceEdit:9856363] Orlic-Milacic, Marija, 2023-12-18 |
| literatureReference | [LiteratureReference:9856351] Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis [LiteratureReference:9828135] H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation |
| modified | [InstanceEdit:9856563] Orlic-Milacic, Marija, 2023-12-19 [InstanceEdit:9856569] Orlic-Milacic, Marija, 2023-12-19 [InstanceEdit:9856570] Orlic-Milacic, Marija, 2023-12-19 [InstanceEdit:9856571] Orlic-Milacic, Marija, 2023-12-20 [InstanceEdit:9856641] Orlic-Milacic, Marija, 2023-12-21 [InstanceEdit:9907518] Orlic-Milacic, Marija, 2024-04-11 |
| text | In differentiating mouse brown adipocytes, KMT2D (MLL4) mainly binds to active ehnancers that are prevalently bound by both CEBP and PPARG, or at least by one of the two adipogenic trancription factors - the experiment did not distinguish between CEBPA and CEBPB (Lee et al. 2013). In mouse embryonic fibroblasts (MEFs), PAXIP1 (PTIP) and PAGR1 (PA1), accessory subunits of the KMT2C (MLL3) and MLL4 complexes,as well as the mandatory subunit RBBP5 and the catalytic subunit KMT2D, are found associated with the PPARG1 but not PPARG2 promoter. PPARG1 is the only isoform of PPARG expressed in MEFs (Cho et al. 2009). KMT2D binds the PPARG gene locus in differentiating mouse brown adipocytes (Lee et al. 2013). By ChIP, at day 2 of mouse brown adipocyte differentiation more than half of KMT2D binding sites overlap with binding sites for CEBPB, CEBPA, and PPARG (Lee et al. 2013). KMT2D physically interacts with CEBPB in mouse differentiating brown adipocytes, and is recruited to more than half of CEBPB-occupied active enhancers in preadipocytes, including PPARG gene enhancers, which is correlated with H3K4 monomethylation (H3K4me1) and H3K27 acetylation (H3K27ac) at enhancers (Lee et al. 2013). |
| (summation) | [Reaction:9851744] CEBPB recruits MLL4,(MLL3) to PPARG gene enhancer [Homo sapiens] |
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No pathways have been reviewed or authored by In differentiating mouse brown adipocytes, KMT2D (MLL4) main... (9856367)
