Query author contributions in Reactome
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Details on Person As assessed by electrophoretic mobility shift assay (EMSA) a...
| Class:Id | Summation:9855876 |
|---|---|
| _displayName | As assessed by electrophoretic mobility shift assay (EMSA) a... |
| _timestamp | 2024-08-01 21:03:16 |
| created | [InstanceEdit:9855875] Rothfels, Karen, 2023-12-07 |
| modified | [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19 [InstanceEdit:9863222] Rothfels, Karen, 2024-02-28 [InstanceEdit:9907117] Rothfels, Karen, 2024-04-04 [InstanceEdit:9917237] Rothfels, Karen, 2024-08-01 |
| text | As assessed by electrophoretic mobility shift assay (EMSA) and chromatin immunopreciptitation (ChIP), MITF-M binds to an M-box element at position-115 and to the related E-box element at the transcriptional start site of the TYR gene to activate transcription (Bentley et al, 1994; Takeda et al, 1998; Galibert et al, 2001; Strub et al, 2011). Some studies have demonstrated that MITF-M binding to the TYR promoter is constitutive and drives basal expression, with UV-inducible expression being driven by the basic helix loop helix protein USF1 downstream of p38 signaling (Bentley et al, 1994; Galibert et al, 2001). MITF-M also recruits the SWI/SNF complex to the promoter, as demonstrated through co-immunoprecipitation of MITF with the SWI/SNF components SMARCA4, SMARCA2, SMARCE1, SMARCB1 and in an additional study, with SMARCD1 and SMARCD2 (de la Serna et al, 2006; Keenaen et al, 2010; Aras et al, 2019). In 501MEL melanoma cells, MITF interacts with the PBAF chromatin remodelling complex containing SMARCA4, PBRM1, SMARCC1, SMARCD2, ACTL6A and CHD7 (Laurette et al, 2015). |
| (summation) | [Reaction:9824981] MITF-M and the SWI/SNF complex bind the TYR promoter [Homo sapiens] |
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No pathways have been reviewed or authored by As assessed by electrophoretic mobility shift assay (EMSA) a... (9855876)
