Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)

Class:IdReaction:9855735
_displayNamefactor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)
_doReleaseTRUE
_timestamp2026-01-27 16:19:37
authored[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
catalystActivity[CatalystActivity:9904350] serine-type endopeptidase activity of FXII:polyanionic activator [extracellular region]
compartment[Compartment:984] extracellular region
created[InstanceEdit:9855678] Shamovsky, Veronica, 2023-12-07
edited[InstanceEdit:9980037] Shamovsky, Veronica, 2026-01-24
input[Complex:9857879] FXII:polyanionic activator [extracellular region] [Homo sapiens]
internalReviewed[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
literatureReference[LiteratureReference:158373] Autoactivation of human Hageman factor. Demonstration utilizing a synthetic substrate.
[LiteratureReference:9655727] Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
[LiteratureReference:9855707] Single-chain factor XII exhibits activity when complexed to polyphosphate
[LiteratureReference:9855754] Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
[LiteratureReference:9660279] Human factor XII (Hageman factor) autoactivation by dextran sulfate. Circular dichroism, fluorescence, and ultraviolet difference spectroscopic studies
modified[InstanceEdit:9857918] Shamovsky, Veronica, 2024-01-09
[InstanceEdit:9904351] Shamovsky, Veronica, 2024-03-28
[InstanceEdit:9936709] Shamovsky, Veronica, 2025-01-25
[InstanceEdit:9937694] Shamovsky, Veronica, 2025-02-05
[InstanceEdit:9938622] Shamovsky, Veronica, 2025-02-18
[InstanceEdit:9938675] Shamovsky, Veronica, 2025-02-18
[InstanceEdit:9938854] Shamovsky, Veronica, 2025-02-20
[InstanceEdit:9946118] Shamovsky, Veronica, 2025-04-21
[InstanceEdit:9979560] Shamovsky, Veronica, 2026-01-20
[InstanceEdit:9980357] Shamovsky, Veronica, 2026-01-27
namefactor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis)
factor XII -> factor XIIa (autocatalysis on polyanionic molecules)
output[Complex:158306] factor XIIa [extracellular region] [Homo sapiens]
[DefinedSet:9855736] polyanionic activators of FXII [extracellular region] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveRegulation:9034633] Positive regulation by 'Zn2+ [extracellular region]'
regulationReference[RegulationReference:9946114] Positive regulation by 'Zn2+ [extracellular region]' Factor XII interacts with the multiprotein assembly of urokinase plasminogen activator receptor, gC1qR, and cytokeratin 1 on endothelial cell membranes
releaseDate2026-03-25
reviewed[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9855756] R-HSA-9855735.1
structureModified[InstanceEdit:9857918] Shamovsky, Veronica, 2024-01-09
[InstanceEdit:9946118] Shamovsky, Veronica, 2025-04-21
summation[Summation:9857899] Autocatalytic cleavage of a single peptide bond after Arg372...
(hasEvent)[Pathway:9769741] Contact activation system [Homo sapiens]
[Pathway:9970672] FXIIa activates plasma kallikrein-kinin system [Homo sapiens]
(precedingEvent)[Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) [Homo sapiens]
[Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens]
[Reaction:9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) (9855735)
Follow Reactome