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Details on Person factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma)

Class:Id	Reaction:9855705
_displayName	factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma)
_doRelease	TRUE
_timestamp	2026-01-27 16:19:07
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9855678] Shamovsky, Veronica, 2023-12-07
edited	[InstanceEdit:9980037] Shamovsky, Veronica, 2026-01-24
input	[EntityWithAccessionedSequence:9855700] factor XII [extracellular region] [Homo sapiens] [DefinedSet:9855736] polyanionic activators of FXII [extracellular region] [Homo sapiens]
internalReviewed	[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
isChimeric	FALSE
literatureReference	[LiteratureReference:9855682] Factor XII Structure-Function Relationships [LiteratureReference:9855754] Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains [LiteratureReference:9855686] Polyphosphate nanoparticles on the platelet surface trigger contact system activation [LiteratureReference:9660279] Human factor XII (Hageman factor) autoactivation by dextran sulfate. Circular dichroism, fluorescence, and ultraviolet difference spectroscopic studies [LiteratureReference:9855707] Single-chain factor XII exhibits activity when complexed to polyphosphate [LiteratureReference:9857874] Activation of the human contact system on neutrophil extracellular traps
modified	[InstanceEdit:9857918] Shamovsky, Veronica, 2024-01-09 [InstanceEdit:9904349] Shamovsky, Veronica, 2024-03-28 [InstanceEdit:9936707] Shamovsky, Veronica, 2025-01-25 [InstanceEdit:9938620] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938675] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938810] Shamovsky, Veronica, 2025-02-19 [InstanceEdit:9938852] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9946118] Shamovsky, Veronica, 2025-04-21 [InstanceEdit:9979556] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980356] Shamovsky, Veronica, 2026-01-27
name	factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) FXII binds plasma polyanionic molecules
output	[Complex:9857879] FXII:polyanionic activator [extracellular region] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
requiredInputComponent	[SimpleEntity:158417] Zn2+ [extracellular region]
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9855760] R-HSA-9855705.1
structureModified	[InstanceEdit:9857918] Shamovsky, Veronica, 2024-01-09
summation	[Summation:9857907] This Reactome event shows binding of factor XII (FXII, also ...
(hasEvent)	[Pathway:9769741] Contact activation system [Homo sapiens] [Pathway:9970672] FXIIa activates plasma kallikrein-kinin system [Homo sapiens]
(precedingEvent)	[Reaction:9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) [Homo sapiens] [Reaction:9936906] factor XII:β-amyloid:Zn2+-> factor XIIa + β-amyloid:Zn2+ (autocatalysis) [Homo sapiens]
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No pathways have been reviewed or authored by factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) (9855705)