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Details on Person Calpain2 cleaves Tln1 (Talin-1)

Class:IdReaction:9855152
_displayNameCalpain2 cleaves Tln1 (Talin-1)
_doReleaseTRUE
_timestamp2024-07-16 10:05:58
authored[InstanceEdit:9855100] May, Bruce, 2023-11-27
catalystActivity[CatalystActivity:9855123] calcium-dependent cysteine-type endopeptidase activity of Calpain2 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9855036] May, Bruce, 2023-11-29
edited[InstanceEdit:9855100] May, Bruce, 2023-11-27
input[EntityWithAccessionedSequence:9855035] Tln1 [cytosol] [Mus musculus]
isChimericFALSE
literatureReference[LiteratureReference:9855119] Calpain-mediated proteolysis of talin regulates adhesion dynamics
[LiteratureReference:9855105] Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing
[LiteratureReference:9863432] Isoform specific function of calpain 2 in regulating membrane protrusion
modified[InstanceEdit:9863444] May, Bruce, 2024-02-29
[InstanceEdit:9915798] May, Bruce, 2024-07-16
nameCalpain2 cleaves Tln1 (Talin-1)
output[EntityWithAccessionedSequence:9855103] Tln1(1-432) [cytosol] [Mus musculus]
[EntityWithAccessionedSequence:9855172] Tln1(433-2541) [cytosol] [Mus musculus]
releaseDate2024-09-11
reviewed[InstanceEdit:9915793] Xiao, Rui, 2024-07-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9855188] R-MMU-9855152.1
summation[Summation:9863388] Calpain2 (m-Calpain) cleaves Tln1 (Talin-1, Talin) between a...
(inferredFrom)[Reaction:9855106] Calpain2 (m-Calpain) cleaves TLN1 (Talin-1) [Homo sapiens]
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No pathways have been reviewed or authored by Calpain2 cleaves Tln1 (Talin-1) (9855152)