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Details on Person MITF-M activates the expression of PPARGC1A by binding to E-...
| Class:Id | Summation:9854915 |
|---|---|
| _displayName | MITF-M activates the expression of PPARGC1A by binding to E-... |
| _timestamp | 2024-01-19 17:56:28 |
| created | [InstanceEdit:9854922] Rothfels, Karen, 2023-11-28 |
| modified | [InstanceEdit:9854931] Rothfels, Karen, 2023-11-28 [InstanceEdit:9859473] Rothfels, Karen, 2024-01-19 |
| text | MITF-M activates the expression of PPARGC1A by binding to E-box elements in its promoter (Haq et al, 2013; Vazquez et al 2013). PPARGC1A is a transcriptional co-activator that has roles in mitochondrial biogenesis and expression of genes involved in oxidative phosphorylation (Mootha et al, 2003; reviewed in Goding and Arnheiter, 2019). Upregulation of PPARGC1A consequently promotes a metabolic shift towards oxidative phosphorylation (Haq et al, 2013; Vazquez et al, 2013; reviewed in Falletta et al, 2022). PPARGC1A has also been identified as a transcriptional activator of MITF-M in concert with SOX10, establishing a positive feedback loop (Shoag et al, 2013). |
| (summation) | [BlackBoxEvent:9854906] MITF-M-dependent PPARGC1A gene expression [Homo sapiens] |
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No pathways have been reviewed or authored by MITF-M activates the expression of PPARGC1A by binding to E-... (9854915)
