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Details on Person MITF-M-dependent PPARGC1A gene expression

Class:Id	BlackBoxEvent:9854906
_displayName	MITF-M-dependent PPARGC1A gene expression
_doRelease	TRUE
_timestamp	2024-11-08 15:57:37
authored	[InstanceEdit:9853077] Rothfels, Karen, 2023-11-10
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9854922] Rothfels, Karen, 2023-11-28
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
input	[EntityWithAccessionedSequence:4686147] PPARGC1A gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9859271] Orlic-Milacic, Marija, 2024-01-17
isChimeric	FALSE
literatureReference	[LiteratureReference:9854822] Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF [LiteratureReference:9854871] PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress [LiteratureReference:9854858] PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9854810] Connecting Metabolic Rewiring With Phenotype Switching in Melanoma [LiteratureReference:9854837] PGC-1 coactivators regulate MITF and the tanning response
modified	[InstanceEdit:9854931] Rothfels, Karen, 2023-11-28 [InstanceEdit:9863248] Rothfels, Karen, 2024-02-28 [InstanceEdit:9910861] Rothfels, Karen, 2024-05-21 [InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent PPARGC1A gene expression
output	[EntityWithAccessionedSequence:442481] PPARGC1A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9854912] MITF-M dimer binds the PPARGC1A promoter [Homo sapiens] [Reaction:9857375] MITF dimerizes [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9854918] Positive gene expression regulation by 'MITF-M dimer:PPARGC1A gene [nucleoplasm]'
regulationReference	[RegulationReference:9854908] Positive gene expression regulation by 'MITF-M:PPARGC1A gene [nucleoplasm]' Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF
releaseDate	2024-03-27
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingrímsson, Eiríkur, 2024-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9854930] R-HSA-9854906.3
summation	[Summation:9854915] MITF-M activates the expression of PPARGC1A by binding to E-...
(hasEvent)	[Pathway:9854907] Regulation of MITF-M dependent genes involved in metabolism [Homo sapiens]
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No pathways have been reviewed or authored by MITF-M-dependent PPARGC1A gene expression (9854906)