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Details on Person SIRT3 deacetylates AcK-IDH2 dimer

Class:Id	Reaction:9854463
_displayName	SIRT3 deacetylates AcK-IDH2 dimer
_doRelease	TRUE
_timestamp	2024-02-15 14:13:52
authored	[InstanceEdit:9854421] Stephan, Ralf, 2023-11-26
catalystActivity	[CatalystActivity:5688302] NAD-dependent protein lysine deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9854461] Stephan, Ralf, 2023-11-27
crossReference	[DatabaseIdentifier:9854455] RHEA:43636
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
input	[SimpleEntity:113526] NAD+ [mitochondrial matrix] [SimpleEntity:113526] NAD+ [mitochondrial matrix] [Complex:9854462] AcK-IDH2 dimer [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
isChimeric	FALSE
literatureReference	[LiteratureReference:5688312] Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation [LiteratureReference:9854456] SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status [LiteratureReference:9854422] Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells [LiteratureReference:9854458] Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension
modified	[InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9859506] Stephan, Ralf, 2024-01-20 [InstanceEdit:9861217] D'Eustachio, Peter, 2024-02-15
name	SIRT3 deacetylates AcK-IDH2 dimer
output	[SimpleEntity:5688274] NAM [mitochondrial matrix] [SimpleEntity:5688274] NAM [mitochondrial matrix] [SimpleEntity:5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix] [SimpleEntity:5688337] 2'-O-acetyl-ADP-ribose [mitochondrial matrix] [Complex:450982] IDH2 dimer [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:9854415] ACAT1 tetramer acetylates IDH2 dimer [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9854465] R-HSA-9854463.1
summation	[Summation:9854459] NAD-dependent protein deacetylase sirtuin-3 (SIRT-3) deacety...
(hasEvent)	[Pathway:9854311] Maturation of TCA enzymes and regulation of TCA cycle [Homo sapiens]
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No pathways have been reviewed or authored by SIRT3 deacetylates AcK-IDH2 dimer (9854463)