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Details on Person ACAT1 tetramer acetylates IDH2 dimer

Class:Id	Reaction:9854415
_displayName	ACAT1 tetramer acetylates IDH2 dimer
_doRelease	TRUE
_timestamp	2024-02-15 14:13:36
authored	[InstanceEdit:9854399] Stephan, Ralf, 2023-11-26
catalystActivity	[CatalystActivity:9854426] acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9854421] Stephan, Ralf, 2023-11-26
crossReference	[DatabaseIdentifier:9854409] RHEA:45948
edited	[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
input	[SimpleEntity:113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:113559] Ac-CoA [mitochondrial matrix] [Complex:450982] IDH2 dimer [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
isChimeric	FALSE
literatureReference	[LiteratureReference:9854428] Regulation of cellular metabolism by protein lysine acetylation [LiteratureReference:9854422] Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
modified	[InstanceEdit:9854461] Stephan, Ralf, 2023-11-27 [InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9859506] Stephan, Ralf, 2024-01-20 [InstanceEdit:9861217] D'Eustachio, Peter, 2024-02-15
name	ACAT1 tetramer acetylates IDH2 dimer
output	[SimpleEntity:29374] CoA-SH [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix] [Complex:9854462] AcK-IDH2 dimer [mitochondrial matrix] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9854437] R-HSA-9854415.1
structureModified	[InstanceEdit:9854461] Stephan, Ralf, 2023-11-27
summation	[Summation:9854411] All enzymes of the TCA cycle are highly acetylated at multip...
(hasEvent)	[Pathway:9854311] Maturation of TCA enzymes and regulation of TCA cycle [Homo sapiens]
(precedingEvent)	[Reaction:9854463] SIRT3 deacetylates AcK-IDH2 dimer [Homo sapiens]
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No pathways have been reviewed or authored by ACAT1 tetramer acetylates IDH2 dimer (9854415)