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Details on Person Frataxin transfers Fe2+ to ACO2

Class:IdReaction:9854405
_displayNameFrataxin transfers Fe2+ to ACO2
_doReleaseTRUE
_timestamp2024-02-15 14:13:42
authored[InstanceEdit:9854370] Stephan, Ralf, 2023-11-26
catalystActivity[CatalystActivity:9855646] iron chaperone activity of 2 Iron:FXN [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:9854399] Stephan, Ralf, 2023-11-26
edited[InstanceEdit:9861216] D'Eustachio, Peter, 2024-02-15
input[Complex:9854373] ACO2:3Fe-4S [mitochondrial matrix] [Homo sapiens]
[Complex:1362402] 2 Iron:FXN [mitochondrial matrix] [Homo sapiens]
internalReviewed[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
isChimericFALSE
literatureReference[LiteratureReference:9854395] Redox sensitive human mitochondrial aconitase and its interaction with frataxin: In vitro and in silico studies confirm that it takes two to tango
[LiteratureReference:9854392] Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity
[LiteratureReference:9854704] Friedreich's ataxia: point mutations and clinical presentation of compound heterozygotes
modified[InstanceEdit:9854696] Stephan, Ralf, 2023-11-28
[InstanceEdit:9855645] Stephan, Ralf, 2023-12-06
[InstanceEdit:9856154] Stephan, Ralf, 2023-12-12
[InstanceEdit:9859506] Stephan, Ralf, 2024-01-20
[InstanceEdit:9861208] Stephan, Ralf, 2024-02-15
[InstanceEdit:9861217] D'Eustachio, Peter, 2024-02-15
nameFrataxin transfers Fe2+ to ACO2
output[Complex:9854344] ACO2:4Fe-4S [mitochondrial matrix] [Homo sapiens]
[EntityWithAccessionedSequence:1362390] FXN(81-210) [mitochondrial matrix] [Homo sapiens]
[SimpleEntity:113531] Fe2+ [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2024-03-27
reviewed[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9854406] R-HSA-9854405.1
structureModified[InstanceEdit:9855645] Stephan, Ralf, 2023-12-06
summation[Summation:9854393] Frataxin (FXN) is an iron chaperone that acts as a protein p...
(hasEvent)[Pathway:9854311] Maturation of TCA enzymes and regulation of TCA cycle [Homo sapiens]
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No pathways have been reviewed or authored by Frataxin transfers Fe2+ to ACO2 (9854405)