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Details on Person ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex

Class:Id	BlackBoxEvent:9854142
_displayName	ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
_doRelease	TRUE
_timestamp	2025-11-04 02:55:40
authored	[InstanceEdit:9854138] Orlic-Milacic, Marija, 2023-11-22
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9854138] Orlic-Milacic, Marija, 2023-11-22
edited	[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
inferredFrom	[BlackBoxEvent:9907194] Elovl5 gene expression is stimulated by Pparg2:Rxra and Mll4,(Mll3) complex [Mus musculus]
input	[EntityWithAccessionedSequence:8962699] ELOVL5 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9907495] May, Bruce, 2024-04-10
isChimeric	FALSE
literatureReference	[LiteratureReference:9842041] Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2
modified	[InstanceEdit:9858002] Orlic-Milacic, Marija, 2024-01-09 [InstanceEdit:9907197] Orlic-Milacic, Marija, 2024-04-04 [InstanceEdit:9907517] Orlic-Milacic, Marija, 2024-04-11 [InstanceEdit:9907535] Orlic-Milacic, Marija, 2024-04-12 [InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9919218] Orlic-Milacic, Marija, 2024-08-19 [InstanceEdit:9971031] Orlic-Milacic, Marija, 2025-11-04
name	ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
output	[EntityWithAccessionedSequence:548679] ELOVL5 [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9851879] MLL4-ASCOM,(MLL3-ASCOM) monomethylates nucleosomes at regulatory elements of steatotic genes [Homo sapiens] [BlackBoxEvent:9851871] MLL4-ASCOM,(MLL3-ASCOM) is recruited to PPARG2-bound regulatory elements of steatotic genes [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9854145] Positive gene expression regulation by 'Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:H3K4me1-nucleosomes:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm]'
releaseDate	2024-09-11
reviewed	[InstanceEdit:9970975] Aberin, Marvin Angelo E, 2025-10-31 [InstanceEdit:9970978] Wang, Shu-Ping, 2025-10-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9854149] R-HSA-9854142.2
summation	[Summation:9857990] Based on a mouse model of hepatic steatosis, expression of t...
(hasEvent)	[Pathway:9841922] MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis [Homo sapiens] [Pathway:9851812] MLL3 and MLL4 regulate expression of PPARG target genes in hepatic steatosis_not ready for review_merged with adipogenesis [Homo sapiens]
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No pathways have been reviewed or authored by ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex (9854142)