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Details on Person ANO6 exposes PS, PE on the platelet membrane

Class:Id	BlackBoxEvent:9853809
_displayName	ANO6 exposes PS, PE on the platelet membrane
_doRelease	TRUE
_timestamp	2026-01-27 16:09:55
authored	[InstanceEdit:9853789] Shamovsky, Veronica, 2023-11-21
catalystActivity	[CatalystActivity:9853793] phospholipid scramblase activity of ANO6:ANO6:Ca2+ [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9853799] phospholipid scramblase activity of ANO6:Ca2+ [plasma membrane] Calcium-dependent phospholipid scrambling by TMEM16F
compartment	[Compartment:947587] cytoplasmic side of plasma membrane [Compartment:876] plasma membrane [Compartment:947586] external side of plasma membrane
created	[InstanceEdit:9853789] Shamovsky, Veronica, 2023-11-21
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[DefinedSet:947588] APLs [cytoplasmic side of plasma membrane]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9853786] TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation [LiteratureReference:9853797] Calcium-dependent phospholipid scrambling by TMEM16F [LiteratureReference:9853811] Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation
modified	[InstanceEdit:9938555] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938649] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938834] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979481] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980318] Shamovsky, Veronica, 2026-01-27
name	ANO6 exposes PS, PE on the platelet membrane TMEM16F exposes PS, PE on platelets
output	[DefinedSet:947594] APLs [external side of plasma membrane]
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9853833] R-HSA-9853809.1
summation	[Summation:9853817] This Reactome event shows Ca²⁺-dependent, anoctamin-6 (ANO6)...
(hasEvent)	[Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(normalReaction)	[FailedReaction:9853849] Defective ANO6 does not expose PS, PE on the platelet membrane [Homo sapiens]
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No pathways have been reviewed or authored by ANO6 exposes PS, PE on the platelet membrane (9853809)