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Details on Person DLST transfers succinyl to CoA

Class:Id	Reaction:9853512
_displayName	DLST transfers succinyl to CoA
_doRelease	TRUE
_timestamp	2024-04-24 07:24:27
authored	[InstanceEdit:9853489] Stephan, Ralf, 2023-11-05
catalystActivity	[CatalystActivity:9853498] dihydrolipoyllysine-residue succinyltransferase activity of OGDH complex [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9853494] Stephan, Ralf, 2023-11-16
crossReference	[DatabaseIdentifier:9853769] RHEA:15215
edited	[InstanceEdit:9859598] Stephan, Ralf, 2024-01-22
input	[SimpleEntity:29374] CoA-SH [mitochondrial matrix] [EntityWithAccessionedSequence:9853502] SuccinyllipoH2-K110-DLST [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9856153] D'Eustachio, Peter, 2023-12-12
isChimeric	FALSE
literatureReference	[LiteratureReference:9853743] Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure [LiteratureReference:9853756] Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas [LiteratureReference:9853979] Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex
modified	[InstanceEdit:9853770] Stephan, Ralf, 2023-11-21 [InstanceEdit:9853986] Stephan, Ralf, 2023-11-22 [InstanceEdit:9854469] Stephan, Ralf, 2023-11-27 [InstanceEdit:9855619] Stephan, Ralf, 2023-12-05 [InstanceEdit:9856154] Stephan, Ralf, 2023-12-12 [InstanceEdit:9859598] Stephan, Ralf, 2024-01-22 [InstanceEdit:9861237] D'Eustachio, Peter, 2024-02-15 [InstanceEdit:9863536] Stephan, Ralf, 2024-03-01 [InstanceEdit:9908912] Stephan, Ralf, 2024-04-24
name	DLST transfers succinyl to CoA (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-(2-oxoglutarate dehydrogenase complex component E2) + CoA => (R)-N(6)-dihydrolipoyl-L-lysyl-(2-oxoglutarate dehydrogenase complex component E2) + succinyl-CoA
negativePrecedingEvent	[NegativePrecedingEvent:9908924] Futile Cycle: SUCLG1/A2 cleaves succinyl-CoA [NegativePrecedingEvent:9908915] Futile Cycle: SUCLG1/G2 cleaves succinyl-CoA
output	[SimpleEntity:70958] SUCC-CoA [mitochondrial matrix] [EntityWithAccessionedSequence:9853485] LipoH2-K110-DLST [mitochondrial matrix] [Homo sapiens]
precedingEvent	[Reaction:71401] OGDH dimer decarboxylates 2-OG [Homo sapiens] [Reaction:70967] IDH3 complex decarboxylates isocitrate [Homo sapiens] [Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [Reaction:450984] IDH2 dimer decarboxylates isocitrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:450971] NNT dimer transfers proton from NADPH to NAD+ [Homo sapiens] [Reaction:70975] CS acetylates OA to citrate [Homo sapiens] [Reaction:70979] MDH2 dimer dehydrogenates MAL [Homo sapiens] [Reaction:70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA [Homo sapiens] [Reaction:9854315] CSKMT methylates Citrate Synthase [Homo sapiens] [Reaction:70501] PC carboxylates PYR to OA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9853517] R-HSA-9853512.2
structureModified	[InstanceEdit:9854469] Stephan, Ralf, 2023-11-27 [InstanceEdit:9855619] Stephan, Ralf, 2023-12-05
summation	[Summation:9853764] Dihydrolipoyl succinyl transferase (DLST), the E2 component ...
(hasEvent)	[Pathway:9853506] OGDH complex synthesizes succinyl-CoA from 2-OG [Homo sapiens]
(precedingEvent)	[Reaction:9853499] DLD dimer dehydrogenates dihydrolipoyl [Homo sapiens] [NegativePrecedingEvent:9908914] Futile Cycle: DLST transfers succinyl to CoA [NegativePrecedingEvent:9908922] Futile Cycle: DLST transfers succinyl to CoA
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