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Details on Person MLL4-ASCOM,(MLL3-ASCOM) monomethylates nucleosomes at regulatory elements of steatotic genes

Class:IdBlackBoxEvent:9851879
_displayNameMLL4-ASCOM,(MLL3-ASCOM) monomethylates nucleosomes at regulatory elements of steatotic genes
_doReleaseFALSE
_timestamp2024-08-14 14:36:45
catalystActivity[CatalystActivity:9853322] histone H3K4 methyltransferase activity of PPARG ligands:p-Y78,Y102-PPARG2:RXRA ligands:RXRA:coactivators:steatotic target genes:nucleosome:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9851878] Orlic-Milacic, Marija, 2023-11-01
edited[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
input[DefinedSet:9851868] PPARG ligands:p-Y78,Y102-PPARG2:RXRA ligands:RXRA:coactivators:steatotic target genes:nucleosome:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Homo sapiens]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
[SimpleEntity:77087] AdoMet [nucleoplasm]
isChimericFALSE
modified[InstanceEdit:9853349] Orlic-Milacic, Marija, 2023-11-15
[InstanceEdit:9857752] Orlic-Milacic, Marija, 2024-01-08
[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
[InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07
[InstanceEdit:9918134] Orlic-Milacic, Marija, 2024-08-14
nameMLL4-ASCOM,(MLL3-ASCOM) monomethylates nucleosomes at regulatory elements of steatotic genes
output[DefinedSet:9853309] PPARG ligands:p-Y78,Y102-PPARG2:RXRA ligands:RXRA:coactivators:steatotic target genes:H3K4me1-nucleosome:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Homo sapiens]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
[SimpleEntity:77502] AdoHcy [nucleoplasm]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9851880] R-HSA-9851879.1
structureModified[InstanceEdit:9853349] Orlic-Milacic, Marija, 2023-11-15
summation[Summation:9857751] Based on a mouse study, MLL4-dependent increase in H3K4me1 l...
(hasEvent)[Pathway:9851812] MLL3 and MLL4 regulate expression of PPARG target genes in hepatic steatosis_not ready for review_merged with adipogenesis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9854127] AGPAT2 gene expression is stimulated by PPARG2 and MLL4(MLL3) [Homo sapiens]
[BlackBoxEvent:9854128] ACSS3 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex [Homo sapiens]
[BlackBoxEvent:9854130] THRSP gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex [Homo sapiens]
[BlackBoxEvent:9854133] SCD gene expression is stimulated by PPARG2 and MLL4(MLL3) [Homo sapiens]
[BlackBoxEvent:9854135] CD36 gene expression is stimulated by PPARG2 and MLL4(MLL3) [Homo sapiens]
[BlackBoxEvent:9854140] PLIN2 gene expression is stimulated by PPARG2 and MLL4(MLL3) [Homo sapiens]
[BlackBoxEvent:9854141] GPAM gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex [Homo sapiens]
[BlackBoxEvent:9854142] ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex [Homo sapiens]
[BlackBoxEvent:9854143] CIDEC gene expression is stimulated by PPARG2 and MLL4(MLL3) [Homo sapiens]
[BlackBoxEvent:9854146] REVIEWERS CONSIDER EVIDENCE INSUFICIENT: SCD5 gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex [Homo sapiens]
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No pathways have been reviewed or authored by MLL4-ASCOM,(MLL3-ASCOM) monomethylates nucleosomes at regulatory elements of steatotic genes (9851879)
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