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Details on Person MLL4-ASCOM,(MLL3-ASCOM) is recruited to PPARG2-bound regulatory elements of steatotic genes

Class:Id	BlackBoxEvent:9851871
_displayName	MLL4-ASCOM,(MLL3-ASCOM) is recruited to PPARG2-bound regulatory elements of steatotic genes
_doRelease	FALSE
_timestamp	2024-08-14 14:36:43
created	[InstanceEdit:9851870] Orlic-Milacic, Marija, 2023-11-01
edited	[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
input	[DefinedSet:9851862] PPARG ligands:p-Y78,Y102-PPARG2:RXRA ligands:RXRA:coactivators:steatotic target genes:nucleosome [nucleoplasm] [Homo sapiens] [CandidateSet:9851869] MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9857748] Orlic-Milacic, Marija, 2024-01-08 [InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9918134] Orlic-Milacic, Marija, 2024-08-14
name	MLL4-ASCOM,(MLL3-ASCOM) is recruited to PPARG2-bound regulatory elements of steatotic genes
output	[DefinedSet:9851868] PPARG ligands:p-Y78,Y102-PPARG2:RXRA ligands:RXRA:coactivators:steatotic target genes:nucleosome:MLL4-ASCOM,(MLL3-ASCOM) [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9851863] Coactivators are recruited to liganded PPARG2:RXRA dimers [Homo sapiens] [BlackBoxEvent:9851855] Corepressors are released from liganded PPARG2:RXRA dimers [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851872] R-HSA-9851871.1
summation	[Summation:9857745] Based on a mouse study, MLL4 binds to regulatory elements of...
(hasEvent)	[Pathway:9851812] MLL3 and MLL4 regulate expression of PPARG target genes in hepatic steatosis_not ready for review_merged with adipogenesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9851879] MLL4-ASCOM,(MLL3-ASCOM) monomethylates nucleosomes at regulatory elements of steatotic genes [Homo sapiens]
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No pathways have been reviewed or authored by MLL4-ASCOM,(MLL3-ASCOM) is recruited to PPARG2-bound regulatory elements of steatotic genes (9851871)