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Details on Person PPARG gene expression is positively regulated by CEBPB and MLL4,(MLL3)

Class:Id	BlackBoxEvent:9851754
_displayName	PPARG gene expression is positively regulated by CEBPB and MLL4,(MLL3)
_doRelease	FALSE
_timestamp	2024-11-11 23:02:44
created	[InstanceEdit:9851758] Orlic-Milacic, Marija, 2023-10-30
edited	[InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07
inferredFrom	[BlackBoxEvent:9856357] Pparg gene expression is positively regulated by Cebpb and Mll4,(Mll3) [Mus musculus]
input	[EntityWithAccessionedSequence:5640205] PPARG gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9828135] H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
modified	[InstanceEdit:9856251] Orlic-Milacic, Marija, 2023-12-14 [InstanceEdit:9856360] Orlic-Milacic, Marija, 2023-12-18 [InstanceEdit:9858021] Orlic-Milacic, Marija, 2024-01-09 [InstanceEdit:9917569] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9917571] Orlic-Milacic, Marija, 2024-08-07 [InstanceEdit:9918134] Orlic-Milacic, Marija, 2024-08-14 [InstanceEdit:9928173] Orlic-Milacic, Marija, 2024-11-11
name	PPARG gene expression is positively regulated by CEBPB and MLL4,(MLL3)
output	[EntityWithAccessionedSequence:9841931] PPARG2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9851757] MLL4,(MLL3) monotmethylate H3K4 at PPARG gene enhancer [Homo sapiens] [Reaction:9851744] CEBPB recruits MLL4,(MLL3) to PPARG gene enhancer [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9851755] Positive gene expression regulation by 'CEBPB:PPARG gene:H3K4me1-Nucleosome:MLL4 complex,(MLL3 complex) [nucleoplasm]' [PositiveRegulation:9858020] Positive regulation by 'BRD4 [nucleoplasm]'
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851763] R-HSA-9851754.1
structureModified	[InstanceEdit:9858021] Orlic-Milacic, Marija, 2024-01-09
summation	[Summation:9856248] Deletion of PAXIP1 gene, encoding one of the mandatory acces...
(hasEvent)	[Pathway:9851708] MLL3 and MLL4 regulate expression of CEBPB target genes at the onset of adipogenesis_not ready for review [Homo sapiens]
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No pathways have been reviewed or authored by PPARG gene expression is positively regulated by CEBPB and MLL4,(MLL3) (9851754)