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Details on Person STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing

Class:IdBlackBoxEvent:9851133
_displayNameSTAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing
_doReleaseTRUE
_timestamp2023-11-08 16:00:08
authored[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
compartment[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created[InstanceEdit:9851134] Rothfels, Karen, 2023-10-12
disease[Disease:9699595] anaplastic large cell lymphoma
[Disease:1500689] cancer
edited[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input[EntityWithAccessionedSequence:9850852] ZAP70 gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9850777] NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
[LiteratureReference:9701758] STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
[LiteratureReference:9846133] STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
modified[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30
[InstanceEdit:9852941] Rothfels, Karen, 2023-11-08
[InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
nameSTAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing
output[EntityWithAccessionedSequence:202397] ZAP70 [cytosol] [Homo sapiens]
regulatedBy[NegativeGeneExpressionRegulation:9850965] Negative gene expression regulation by 'DNMT1 [nucleoplasm]'
[NegativeGeneExpressionRegulation:9850968] Negative gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]'
regulationReference[RegulationReference:9851010] Negative gene expression regulation by 'DNMT1 [nucleoplasm]' NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
[RegulationReference:9851014] Negative gene expression regulation by 'p-Y705,S727-STAT3 dimer [nucleoplasm]' NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
releaseDate2023-12-06
reviewed[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9851135] R-HSA-9851133.1
summation[Summation:9850802] Expression of ZAP70 and other components of the TCR signalin...
(hasEvent)[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
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No pathways have been reviewed or authored by STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing (9851133)
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