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Details on Person NPM1-ALK-dependent repression of pRB phosphorylation

Class:Id	BlackBoxEvent:9851127
_displayName	NPM1-ALK-dependent repression of pRB phosphorylation
_doRelease	TRUE
_timestamp	2023-11-08 16:00:04
authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9851128] Rothfels, Karen, 2023-10-12
disease	[Disease:9699595] anaplastic large cell lymphoma [Disease:1500689] cancer
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[EntityWithAccessionedSequence:68642] RB1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9850784] The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway [LiteratureReference:9850767] Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization
modified	[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9851897] Rothfels, Karen, 2023-11-02 [InstanceEdit:9852941] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	NPM1-ALK-dependent repression of pRB phosphorylation
output	[EntityWithAccessionedSequence:188389] hyperphosphorylated RB1 [nucleoplasm] [Homo sapiens]
regulatedBy	[NegativeRegulation:9850973] Negative regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]'
regulationReference	[RegulationReference:9851018] Negative regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]' The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851129] R-HSA-9851127.1
summation	[Summation:9850830] Before NPM1-ALK-containing ALCL cells progress to unrestrain...
(hasEvent)	[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
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No pathways have been reviewed or authored by NPM1-ALK-dependent repression of pRB phosphorylation (9851127)