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Details on Person p-Y705,S727 STAT3 dimer binds NOTCH gene

Class:Id	Reaction:9851122
_displayName	p-Y705,S727 STAT3 dimer binds NOTCH gene
_doRelease	TRUE
_timestamp	2023-11-08 16:00:22
authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9851124] Rothfels, Karen, 2023-10-12
disease	[Disease:9699595] anaplastic large cell lymphoma [Disease:1500689] cancer
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[EntityWithAccessionedSequence:1911481] NOTCH1 gene [nucleoplasm] [Homo sapiens] [Complex:9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9846160] Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target
modified	[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9851897] Rothfels, Karen, 2023-11-02 [InstanceEdit:9852941] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	p-Y705,S727 STAT3 dimer binds NOTCH gene
output	[Complex:9850937] p-Y705,S727 -STAT3 dimer: NOTCH gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants [Homo sapiens] [Reaction:9712085] ALK mutants phosphorylate STAT3 [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851126] R-HSA-9851122.1
summation	[Summation:9850816] Phosphorylated STAT3 binds to the promoter of the NOTCH gene...
(hasEvent)	[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9851123] NPM1-ALK- and p-STAT3-dependent NOTCH gene expression [Homo sapiens]
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No pathways have been reviewed or authored by p-Y705,S727 STAT3 dimer binds NOTCH gene (9851122)