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Details on Person NPM1-ALK-dependent TYK2 phosphorylation

Class:Id	Reaction:9851114
_displayName	NPM1-ALK-dependent TYK2 phosphorylation
_doRelease	TRUE
_timestamp	2023-11-08 16:00:03
authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9851113] Rothfels, Karen, 2023-10-12
disease	[Disease:9699595] anaplastic large cell lymphoma [Disease:1500689] cancer
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[EntityWithAccessionedSequence:877348] TYK2 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9845995] Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
modified	[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9852941] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	NPM1-ALK-dependent TYK2 phosphorylation
output	[EntityWithAccessionedSequence:909682] p-Y1054,Y1055-TYK2 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
regulatedBy	[PositiveRegulation:9850998] Positive regulation by 'NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol]' [PositiveGeneExpressionRegulation:6785078] Positive gene expression regulation by 'IL10 [extracellular region]' [PositiveRegulation:9850996] Positive regulation by 'IL22 [extracellular region]'
regulationReference	[RegulationReference:9851048] Positive regulation by 'NPM dimer [cytosol]' Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma [RegulationReference:9851044] Positive regulation by 'IL10 [extracellular region]' Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma [RegulationReference:9851046] Positive regulation by 'IL22 [extracellular region]' Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851115] R-HSA-9851114.1
summation	[Summation:9850797] The JAK family member TYK2 is phosphorylated in anaplastic l...
(hasEvent)	[Pathway:9725370] Signaling by ALK fusions and activated point mutants [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9851112] NPM1-ALK- and TYK2-dependent MCL1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by NPM1-ALK-dependent TYK2 phosphorylation (9851114)