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Details on Person NPM1-ALK- and TYK2-dependent MCL1 gene expression

Class:Id	BlackBoxEvent:9851112
_displayName	NPM1-ALK- and TYK2-dependent MCL1 gene expression
_doRelease	TRUE
_timestamp	2023-11-08 15:59:57
authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9851113] Rothfels, Karen, 2023-10-12
disease	[Disease:9699595] anaplastic large cell lymphoma [Disease:1500689] cancer
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[EntityWithAccessionedSequence:8948437] MCL1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9845995] Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma [LiteratureReference:9845989] Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils [LiteratureReference:9846114] Overexpression of Mcl-1 in anaplastic large cell lymphoma cell lines and tumors
modified	[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9852941] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	NPM1-ALK- and TYK2-dependent MCL1 gene expression
output	[EntityWithAccessionedSequence:5661490] MCL1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9851114] NPM1-ALK-dependent TYK2 phosphorylation [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9850988] Positive gene expression regulation by 'p-Y1054,Y1055-TYK2 [cytosol]'
regulationReference	[RegulationReference:9851036] Positive gene expression regulation by 'p-Y1054,Y1055-TYK2 [cytosol]' Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851116] R-HSA-9851112.1
summation	[Summation:9850813] MCL1 is a pro-survival member of the BCL2 family. MCL1 is up...
(hasEvent)	[Pathway:9725370] Signaling by ALK fusions and activated point mutants [Homo sapiens]
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No pathways have been reviewed or authored by NPM1-ALK- and TYK2-dependent MCL1 gene expression (9851112)