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Details on Person AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter

Class:Id	Reaction:9851064
_displayName	AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter
_doRelease	TRUE
_timestamp	2023-11-08 15:59:20
authored	[InstanceEdit:9851210] Rothfels, Karen, 2023-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9851065] Rothfels, Karen, 2023-10-12
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
input	[EntityWithAccessionedSequence:5660405] DNMT1 gene [nucleoplasm] [Homo sapiens] [Complex:9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9846132] STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes [LiteratureReference:9850777] NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells [LiteratureReference:9701299] IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
modified	[InstanceEdit:9851737] Rothfels, Karen, 2023-10-30 [InstanceEdit:9852941] Rothfels, Karen, 2023-11-08 [InstanceEdit:9852942] Rothfels, Karen, 2023-11-08
name	AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter
output	[Complex:9850875] AcK685-p-Y705, S727-STAT3 dimer:DNMT1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9701531] p-Y705,S727 STAT3 is acetylated [Homo sapiens] [BlackBoxEvent:9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus [Homo sapiens]
releaseDate	2023-12-06
reviewed	[InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9851066] R-HSA-9851064.1
summation	[Summation:9850810] STAT3 binds to the promoter of DNMT1 to stimulate gene expre...
(hasEvent)	[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9851137] STAT3-dependent DNMT1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter (9851064)