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Details on Person STAT3 binds to the promoter of DNMT1 to stimulate gene expre...
| Class:Id | Summation:9850810 |
|---|---|
| _displayName | STAT3 binds to the promoter of DNMT1 to stimulate gene expre... |
| _timestamp | 2023-10-12 18:30:00 |
| created | [InstanceEdit:9850804] Rothfels, Karen, 2023-10-12 |
| text | STAT3 binds to the promoter of DNMT1 to stimulate gene expression as assessed by chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift assay (EMSA) (Zhang et al, 2006; Ambrogio et al, 2009). In the context of NPM1-ALK signaling in anaplastic large cell leukemia (ALCL), STAT3 signaling also regulates DNMT1 activity by downregulating expression of miR-21, a microRNA that represses translation on DNMT1 mRNA (Zhang et al, 2011). |
| (summation) | [Reaction:9851064] AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter [Homo sapiens] |
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No pathways have been reviewed or authored by STAT3 binds to the promoter of DNMT1 to stimulate gene expre... (9850810)
